原料药
Choline Fenofibrate
KDMF APIs
Choline Fenofibrate
韩文名称 | 페노피브레이트콜린 |
|---|---|
分类 | 中枢神经系统药物 |
CAS No. | 856676-23-8 |
KDMF 登记号 | 20180814-209-J-48(3) |
生产厂商 | Alembic Pharmaceuticals Limited(API Unit-1) |
规格 | In-house |
品目信息
Synonyms | Fenofibric acid choline salt |
|---|---|
Description | Fenofibrate is a third generation fibric acid derivative that is predominantly administered as monotherapy to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B and alternatively to increase high-density lipoprotein cholesterol in patients diagnosed with primary hyperlipidemia or mixed dyslipidemia and to reduce triglycerides in patients with severe hypertriglyceridemia. Fenofibrate however is generally extremely lipophilic, largely insoluble in water, and poorly absorbed 1 . As the primary active metabolite of fenofibrate however, various hydrophilic salt formulations of fenofibric acid have since been developed, resulting in therapeutic agents that demonstrate far greater solubility, absorption throughout the gastrointestinal tract, bioavailability, and capability to be administered irrespective of patient food intake |
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