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원료의약품

Sildenafil Citrate (실데나필시트르산염)

KDMF APIs

Sildenafil Citrate

Sildenafil Citrate 기본 정보

품목명 (한글)

실데나필시트르산염

분류

비뇨생식기관 및 항문

CAS No.

171599-83-0

KDMF 등록번호

20200602-211-J-644

제조원

Mylan Laboratories Limited

규격

EP

품목 정보

Sildenafil Citrate 품목 정보

IUPAC Name

Piperazine,1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Synonyms

1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate (1:1) 5-[2-ethoxy-5-(4-methylpiperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one citrate 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Description

When NO is locally released from sexual stimulation, sildenafil inhibits PDE5 and increases the amount of cGMP in the corpus cavernosum, which relaxes smooth muscles and increases blood flow into the corpus cavernosum, producing an erection. Recommended dose of sildenafil has no effect in the absence of sexual stimulation. PDE5 is present in other tissues including platelets, abdominal smooth muscle, skeletal muscle, which may be the basis for inhibition of platelet thrombogenesis and peripheral arteriovenous dilatation.

Certificate of Analysis

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