CN

原料药

Paroxetine Hydrochloride Hydrate

KDMF APIs

Paroxetine Hydrochloride Hydrate

Paroxetine Hydrochloride Hydrate 基本信息

韩文名称

파록세틴염산염수화물

分类

中枢神经系统药物

CAS No.

61869-08-7

KDMF 登记号

20191217-209-J-318

生产厂商

Mylan Laboratories Limited

规格

EP

品目信息

Paroxetine Hydrochloride Hydrate 品目信息

IUPAC Name

(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine

Synonyms

(−)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

Description

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.

Certificate of Analysis

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