原料药
Doxofylline
KDMF APIs
Doxofylline
韩文名称 | 독소필린 |
|---|---|
分类 | 呼吸系统 |
CAS No. | 69975-86-6 |
KDMF 登记号 | 20181029-209-J-98 |
生产厂商 | Ami Lifesciences Private Limited. |
规格 | In-house |
品目信息
IUPAC Name | 7-[(1,3-dioxolan-2-yl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione |
|---|---|
Synonyms | Doxophylline |
Description | Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. In contrast with other xanthine derivatives, doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. Decreased affinity for adenosine receptors may account for the better safety profile of doxofylline compared to theophylline . Unlike theophylline, doxofylline does not affect calcium influx and does not antagonize the actions of calcium channel blockers which could explain reduced cardiac adverse reactions associated with the drug. The anti-asthmatic effects of doxophylline are mediated by other mechanisms, primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme. |
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