API
Terbinafine Hydrochloride
KDMF APIs
Terbinafine Hydrochloride
Korean name | 테르비나핀염산염 |
|---|---|
Category | Integument |
CAS No. | 91161-71-6 |
KDMF registration No. | 20190322-49-A-349-21 20050905-49-A-94-10(11) |
Manufacturer | Zhejiang East-Asia Pharmaceutical Co., Ltd. |
Specification | EP |
Product information
IUPAC Name | [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine |
|---|---|
Synonyms | (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine |
Description | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway. Terbinafine hydrochloride was granted FDA approval on 30 December 1992. |
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