API
Cimetidine
KDMF APIs
Cimetidine
Korean name | 시메티딘 |
|---|---|
Category | Digestive organs |
CAS No. | 51481-61-9 |
KDMF registration No. | 20060302-27-B-229-04(3) |
Manufacturer | Union quimico farmaceutica, S.A |
Specification | USP |
Product information
IUPAC Name | (Z)-N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine |
|---|---|
Synonyms | 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine |
Description | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. |
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