API
Levofloxacin hydrate
KDMF APIs
Levofloxacin hydrate
Korean name | 레보플록사신수화물 |
|---|---|
Category | Chemotherapeutics |
CAS No. | 1381997-71-0 |
KDMF registration No. | 20100414-102-F-50-10(10) |
Manufacturer | Zhejiang East-Asia Pharmaceutical Co., Ltd. |
Specification | USP |
Product information
IUPAC Name | bis((2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid) hydrate |
|---|---|
Synonyms | L-ofloxacin / Levofloxacin / Levofloxacin (as hemihydrate) / Levofloxacin hydrate / Ofloxacin S-(-)-form hemihydrate |
Description | Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racem ic ofloxacin . It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin 1 and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as gatifloxacin and moxifloxacin , is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections. Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and se veral South American countries soon after. 1 |
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